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DeCS
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Descriptor English:
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Multiple Endocrine Neoplasia Type 1
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Descriptor Spanish:
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Neoplasia Endocrina Múltiple Tipo 1
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Descriptor Portuguese:
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Neoplasia Endócrina Múltipla Tipo 1
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Synonyms English:
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Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasms Type 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type I
Wermer Syndrome
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Tree Number:
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C04.588.322.400.500
C04.651.600.500
C04.700.630.500
C16.320.700.630.500
C19.344.400.500
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Definition English:
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A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13). |
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Indexing Annotation English:
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coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
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History Note English:
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95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
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Allowable Qualifiers English:
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Record Number:
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32134
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Unique Identifier:
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D018761
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Occurrence in VHL:
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Similar:
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DeCS
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